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EP 113: Harnessing human genetics to discover co-evolved small molecule medicines with Dr. Jason Park, CEO of Empress Therapeutics
MP3•Thuis aflevering
Manage episode 388131882 series 2631947
Inhoud geleverd door Sano Genetics. Alle podcastinhoud, inclusief afleveringen, afbeeldingen en podcastbeschrijvingen, wordt rechtstreeks geüpload en geleverd door Sano Genetics of hun podcastplatformpartner. Als u denkt dat iemand uw auteursrechtelijk beschermde werk zonder uw toestemming gebruikt, kunt u het hier beschreven proces https://nl.player.fm/legal volgen.
In this episode of The Genetics Podcast, we welcome Dr. Jason, founder and CEO of Empress Therapeutics, a Flagship Pioneering company. Join us as we discuss how human genetics can identify small molecules with therapeutic potential that are already created by our bodies, paving the way for faster discovery of new medicines.
Summary:
Summary:
0:00 Intro
1:20 Understanding parts of the genome that create and modify small molecules
5:50 The central dogma of molecular biology
8:50 Jason’s background founding biotech companies
11:45 Flagship pioneering: combining scientific discovery and engineering innovations
13:10 The foundation of Empress Therapeutics: biological insight, data, and artificial intelligence
19:30 Learning from disease states and following the thread from DNA to small molecule
22:20 Differences in genetic chemistry across people and case studies
25:30 Potential biological limitations of the small molecule approach
28:00 Using human genetics and synthetic biology to create impactful medicines
32:00 What happens in ‘stealth mode’
36:00 The limiting reactant of scaling small molecule therapies to a wider platform
38:20 The role of the metagenome
40:00 Lessons learned from founding multiple companies
42:20 Origins of the name Empress Therapeutics
43:40 Closing remarks
179 afleveringen
MP3•Thuis aflevering
Manage episode 388131882 series 2631947
Inhoud geleverd door Sano Genetics. Alle podcastinhoud, inclusief afleveringen, afbeeldingen en podcastbeschrijvingen, wordt rechtstreeks geüpload en geleverd door Sano Genetics of hun podcastplatformpartner. Als u denkt dat iemand uw auteursrechtelijk beschermde werk zonder uw toestemming gebruikt, kunt u het hier beschreven proces https://nl.player.fm/legal volgen.
In this episode of The Genetics Podcast, we welcome Dr. Jason, founder and CEO of Empress Therapeutics, a Flagship Pioneering company. Join us as we discuss how human genetics can identify small molecules with therapeutic potential that are already created by our bodies, paving the way for faster discovery of new medicines.
Summary:
Summary:
0:00 Intro
1:20 Understanding parts of the genome that create and modify small molecules
5:50 The central dogma of molecular biology
8:50 Jason’s background founding biotech companies
11:45 Flagship pioneering: combining scientific discovery and engineering innovations
13:10 The foundation of Empress Therapeutics: biological insight, data, and artificial intelligence
19:30 Learning from disease states and following the thread from DNA to small molecule
22:20 Differences in genetic chemistry across people and case studies
25:30 Potential biological limitations of the small molecule approach
28:00 Using human genetics and synthetic biology to create impactful medicines
32:00 What happens in ‘stealth mode’
36:00 The limiting reactant of scaling small molecule therapies to a wider platform
38:20 The role of the metagenome
40:00 Lessons learned from founding multiple companies
42:20 Origins of the name Empress Therapeutics
43:40 Closing remarks
179 afleveringen
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