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Ep. 6 Science SNiP: Forensic DNA Phenotyping, Predicting Human Appearance
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DNA as the "Biological Witness". Forensic DNA Phenotyping predicts the externally visible characteristics - i.e. what a person may look like - from their biological material. It has applications in criminal investigations when other leads have failed, missing persons identification, and anthropological research.
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Links to material discussed in this episode and other links of interest:
King Richard III Identification
Double-murder case example
Missing Person Identification
ACLU Opinion on FDP
Walsh Laboratory
HIrisplex at Erasmus University
Kayser M. Forensic DNA Phenotyping: Predicting human appearance from crime scene material for investigative purposes. Forensic Sci Int Genet. 2015 Sep;18:33-48. doi: 10.1016/j.fsigen.2015.02.003. Epub 2015 Feb 16. PMID: 25716572.
Chaitanya L, Breslin K, Zuñiga S, Wirken L, Pośpiech E, Kukla-Bartoszek M, Sijen T, Knijff P, Liu F, Branicki W, Kayser M, Walsh S. The HIrisPlex-S system for eye, hair and skin colour prediction from DNA: Introduction and forensic developmental validation. Forensic Sci Int Genet. 2018 Jul;35:123-135. doi: 10.1016/j.fsigen.2018.04.004. Epub 2018 Apr 12. PMID: 29753263.
Liu F, van Duijn K, Vingerling JR, Hofman A, Uitterlinden AG, Janssens AC, Kayser M. Eye color and the prediction of complex phenotypes from genotypes. Curr Biol. 2009 Mar 10;19(5):R192-3. doi: 10.1016/j.cub.2009.01.027. PMID: 19278628.
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