Cyclic ADP-ribose

random Wiki of the Day

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rWotD Episode 2712: Cyclic ADP-ribose
Welcome to Random Wiki of the Day, your journey through Wikipedia’s vast and varied content, one random article at a time.
The random article for Sunday, 6 October 2024 is Cyclic ADP-ribose.
Cyclic ADP-ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine (like ADP), further connected to another ribose at the 5' position, which, in turn, closes the cycle by glycosidic bonding to the nitrogen 1 (N1) of the same adenine base (whose position N9 has the glycosidic bond to the other ribose). The N1-glycosidic bond to adenine is what distinguishes cADPR from ADP-ribose (ADPR), the non-cyclic analog. cADPR is produced from nicotinamide adenine dinucleotide (NAD+) by ADP-ribosyl cyclases (EC 3.2.2.5) as part of a second messenger system.
This recording reflects the Wikipedia text as of 00:06 UTC on Sunday, 6 October 2024.
For the full current version of the article, see Cyclic ADP-ribose on Wikipedia.
This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.
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Until next time, I'm standard Emma.

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