Epic Bio - gene editing without cutting DNA

Beyond Biotech - the podcast from Labiotech

Epic Bio is an epigenetic editing company, leveraging the power of CRISPR without cutting DNA.
The company’s proprietary Gene Expression Modulation System (GEMS) includes the smallest Cas protein known to work in human cells, enabling in vivo or ex vivo delivery via a single viral vector.

This week, we discuss epigenetic editing, why it’s reversible, and how it can treat FSHD and other conditions, with Epic Bio’s founder, Dr Stanley Qi, one of the original inventors of CRISPR.

01:15-02:51: Dr Xi’s background
02:51-05:11: The beginning of Epic Bio
05:12-09:23: What is epigenetic editing?
09:23-10:47: What is the Gene Expression Modulation System?
10:47-12:47: How is the editing reversible?
12:47-18:01: How will epigenetic editing advance treatments?
18:01-21:24: Tackling multiple conditions
21:24-22:46: How will your platform tackle FSHD?
22:46-24:18: FSHD clinical trial
24:18-25:51: How will you address costs?
25:51-27:18: Are other companies working on epigenetics?
27:18-29:27: What else is in the pipeline?
29:27-31:58: What are the next steps?

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Hoofdstukken

1. Epic Bio - gene editing without cutting DNA (00:00:00)

2. Dr Xi’s background (00:01:15)

3. About Epic Bio (00:02:51)

4. What is epigenetic editing? (00:05:12)

5. What is the Gene Expression Modulation System?
 (00:09:23)

6. How is the editing reversible?
 (00:10:47)

7. How will epigenetic editing advance treatments? (00:12:47)

8. Tackling multiple conditions (00:18:01)

9. How will your platform tackle FSHD?
 (00:21:24)

10. FSHD clinical trial
 (00:22:46)

11. How will you address costs?
 (00:24:18)

12. Are other companies working on epigenetic editing?
 (00:25:51)

13. What else is in the pipeline?
 (00:27:18)

14. What are the next steps? (00:29:27)