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Stuart J. Schnitt, MD - A New View of the Spectrum of HER2 Expression and Significance of HER2 Low in Breast Cancer: Exploring the Biology and Updating Best Practices for Testing and Treatment

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Manage episode 361947861 series 41876
Inhoud geleverd door PeerView, 24 West 40th Street, Suite 950, New York, NY 10018, PVI, and PeerView Institute for Medical Education. Alle podcastinhoud, inclusief afleveringen, afbeeldingen en podcastbeschrijvingen, wordt rechtstreeks geüpload en geleverd door PeerView, 24 West 40th Street, Suite 950, New York, NY 10018, PVI, and PeerView Institute for Medical Education of hun podcastplatformpartner. Als u denkt dat iemand uw auteursrechtelijk beschermde werk zonder uw toestemming gebruikt, kunt u het hier beschreven proces https://nl.player.fm/legal volgen.
Go online to PeerView.com/NRG860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. HER2-low breast cancer, currently defined as HER2 IHC 1+ or 2+/ISH-, accounts for approximately 50% of all breast cancers. While older HER2-targeted therapies did not show efficacy in HER2-low breast cancers, novel antibody–drug conjugates (ADCs) have demonstrated remarkable activity in this setting. Because of these advances and the FDA approval of the first HER2-targeting ADC for HER2-low breast cancer, there is an urgent need to rethink the approaches to HER2 testing so that patients with HER2-low breast cancer could be identified and get a chance to benefit from the new therapeutic approach. The understanding, definitions, and testing for HER2-low status continue to evolve, and many practical challenges and unanswered questions remain. This PeerView educational activity, based on a recent live symposium, explores the most cutting-edge information on HER2-low breast cancer, provides guidance on how to currently carry out HER2 testing to capture patients with HER2-low expression, and shares what’s on the horizon that may help further refine testing and treatment in this setting. Upon completion of this activity, participants should be better able to: Describe the spectrum of HER2 expression in breast cancer and the role of HER2-low expression as a new therapeutic target; Implement standard and emerging testing approaches to identify patients with HER2-low metastatic breast cancer to determine their eligibility for novel HER2-targeted therapies; Apply the latest evidence and guidelines to integrate HER2-targeted therapies into treatment plans for eligible patients with HER2-low metastatic breast cancer in the context of clinical practice or clinical trials; and Collaborate with the multidisciplinary team to ensure appropriate biomarker testing and optimal treatment selection for patients with HER2-low metastatic breast cancer.
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Artwork
iconDelen
 
Manage episode 361947861 series 41876
Inhoud geleverd door PeerView, 24 West 40th Street, Suite 950, New York, NY 10018, PVI, and PeerView Institute for Medical Education. Alle podcastinhoud, inclusief afleveringen, afbeeldingen en podcastbeschrijvingen, wordt rechtstreeks geüpload en geleverd door PeerView, 24 West 40th Street, Suite 950, New York, NY 10018, PVI, and PeerView Institute for Medical Education of hun podcastplatformpartner. Als u denkt dat iemand uw auteursrechtelijk beschermde werk zonder uw toestemming gebruikt, kunt u het hier beschreven proces https://nl.player.fm/legal volgen.
Go online to PeerView.com/NRG860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. HER2-low breast cancer, currently defined as HER2 IHC 1+ or 2+/ISH-, accounts for approximately 50% of all breast cancers. While older HER2-targeted therapies did not show efficacy in HER2-low breast cancers, novel antibody–drug conjugates (ADCs) have demonstrated remarkable activity in this setting. Because of these advances and the FDA approval of the first HER2-targeting ADC for HER2-low breast cancer, there is an urgent need to rethink the approaches to HER2 testing so that patients with HER2-low breast cancer could be identified and get a chance to benefit from the new therapeutic approach. The understanding, definitions, and testing for HER2-low status continue to evolve, and many practical challenges and unanswered questions remain. This PeerView educational activity, based on a recent live symposium, explores the most cutting-edge information on HER2-low breast cancer, provides guidance on how to currently carry out HER2 testing to capture patients with HER2-low expression, and shares what’s on the horizon that may help further refine testing and treatment in this setting. Upon completion of this activity, participants should be better able to: Describe the spectrum of HER2 expression in breast cancer and the role of HER2-low expression as a new therapeutic target; Implement standard and emerging testing approaches to identify patients with HER2-low metastatic breast cancer to determine their eligibility for novel HER2-targeted therapies; Apply the latest evidence and guidelines to integrate HER2-targeted therapies into treatment plans for eligible patients with HER2-low metastatic breast cancer in the context of clinical practice or clinical trials; and Collaborate with the multidisciplinary team to ensure appropriate biomarker testing and optimal treatment selection for patients with HER2-low metastatic breast cancer.
  continue reading

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