Welcome to MedEvidence Articles, where we encourage community research and education with weekly articles. Visit our website at MedEvidence.com. MedEvidence helps answer the question of “Who can you trust?” for medical information. The MedEvidence platform provides valuable information about many medical issues and the insights of evidence-based medicine. MedEvidence educates audiences through engaging and entertaining magazines, podcasts, videos, articles, and presentations. We strive to br ...
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Medical treatments are shifting from broad approaches to precise genetic targeting, especially for finicky diseases like Alzheimer's dementia. While many past efforts focused on amyloid β plaques, new research is exploring genetic regulators like APP, which influences amyloid levels, and KDM5, an enzyme linked to memory and cognition. Clinical tria…
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This St. Patrick's Day we explore the history, nutritional profile, and potential health benefits of potatoes. Potatoes are a major global food staple, providing significant calories worldwide. Though often criticized for their high glycemic index (GI), different cooking methods, particularly chilling after cooking, can increase resistant starches,…
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In this week's episode, we discuss cluster headaches, one of the most severe pain conditions known. This rare condition affects about one in a thousand people with excruciating, clockwork-like attacks can last for weeks or months, with few effective treatment options. In this episode, we break down the causes, triggers, and latest research on clust…
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Forgetting a name or misplacing your keys can be frustrating, but when does memory loss signal something more serious? In this episode, we explain the key differences between normal aging and Alzheimer’s disease. We break down how doctors diagnose Alzheimer’s, the role of biomarkers, and why early detection is crucial for those considering clinical…
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This week, we talk about one of the big contributors to heart failure: inflammation. Heart failure affects millions and comes in two main types: HFrEF (weakened pumping) and HFpEF (thickened, stiff walls). While conditions like high blood pressure and diabetes contribute, chronic inflammation—driven in part by Interleukin 6 (IL-6)—plays a major rol…
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When the hot water went out, you might call a plumber, but if the water heater is out it might instead be an electrical problem - just like how heart problems can stem from faulty electrical signals rather than the heart muscle itself. Atrial fibrillation (AFib), the most common arrhythmia affecting six million Americans, disrupts the heart’s elect…
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This week's podcast is a crash course on what the heart is, why we need it, how it works, and what can go wrong. Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram Twitter LinkedIn Tiktok Youtube For more great content, including disc…
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This week we talk about two recent studies which suggest a potential link between adult ADHD and an increased risk of developing dementia; though causation remains unproven. These studies, one in Israel and another in Sweden, found that adults with ADHD were significantly more likely to develop dementia or mild cognitive impairment. These findings …
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This week we discuss peripheral artery disease (PAD), a condition affecting blood flow in the peripheral arteries, most commonly in the legs. We cover its symptoms, such as leg pain, skin changes, and slow-healing wounds, as well as the potential risks of untreated PAD, including amputation and cardiovascular complications. We then talk about treat…
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This episode explores atherosclerotic cardiovascular disease (ASCVD), the leading cause of heart attacks and strokes worldwide. Learn about the role of LDL cholesterol in the development of fatty plaques that harden and block blood vessels, as well as the risks associated with ASCVD, including heart disease and peripheral artery disease. The episod…
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Join us this week for a brief tour of some body systems as we review five medications approved by the FDA in 2024. From liver disease to Alzheimer’s, we look at Rezdiffra, Iqirvo, Vafseo, Entyvio, and Kisunla, exploring the diseases they intend to treat and a brief overview of how the medicines work. We celebrate the hard work of volunteers, invest…
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In this episode, we delve into the complexities of Seasonal Affective Disorder (SAD), a subtype of Major Depressive Disorder that fluctuates with the seasons. Seasonal Affective Disorder, a condition affecting millions during the darker months. We explore its symptoms, causes, and demographic prevalence, highlighting its impact on mood, cognition, …
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This week we discuss episodic and chronic migraines. Migraines are primary headaches that affect about a billion people globally each year. In this weeks episode, we discuss symptoms and the differences between episodic and chronic migraines. Learn about risk factors, treatment options, and why accurate and appropriate treatment is critical to keep…
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This podcast episode examines the challenges of sticking to fitness resolutions and how to make exercise more accessible and sustainable. We discuss the health benefits of physical activity, the impact of stress on the body, and why reducing barriers like time, cost, and convenience can improve consistency. Learn practical tips for incorporating fi…
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This week, we dive into the fascinating world of exosomes, the body’s nano-sized delivery drivers and communication hubs. We’ll explore what exosomes are, their role in cell-to-cell communication and healing, and the potential medical applications they offer. These include drug delivery, regenerative medicine, and combating diseases like cancer and…
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Sinus headaches are annoying, bothersome, and might not really be sinus-related for most people! We look at research that explains why sinus inflammation is rarely the cause headaches above the sinuses and how accurate diagnosis is essential for effective treatment. Learn about the role of sinuses, why facial pain isn’t always what it seems, and ho…
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As we approach Thanksgiving and gather with family, it's the perfect time to ponder how our genetics, from eye color to cholesterol levels, shape our lives in unique and sometimes dangerous ways. This episode sheds explores how genetic disorders run in families and looks at lipoprotein (a), a very very very very bad kind of cholesterol. We also lea…
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In this episode we unpack the facts, controversies, and benefits surrounding the most prescribed drugs for lowering “bad” LDL cholesterol. Statins reduce risks of heart attack, stroke, and cardiovascular death, yet concerns over side effects - like muscle pain and blood sugar increases - fuel debates around their use. We’ll explore how statins work…
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In this week's episode we explore how trauma affects many system in the body, with symptoms that can last years or even decades. PTSD impacts not only mental health but also physical health, causing chronic stress that can lead to cardiovascular issues, metabolic changes, and immune dysfunction. We’ll break down the science behind stress responses …
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In this week's episode we dive into how chronic inflammation connects kidney disease with cardiovascular risk. Learn how inflammation, typically the body’s healing response, can become a destructive force when it lingers, contributing to kidney damage and cardiovascular issues like high blood pressure and artery hardening. We’ll also explore why CK…
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This week we explore the science behind one of an increasingly popular approach to managing weight and health—intermittent fasting. We'll break down how limiting your eating window can influence everything from metabolism and inflammation to blood sugar control. With new research showing potential benefits like weight loss and improved glucose leve…
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In this week's episode we take a closer look at the high-sensitivity C-reactive protein (hs-CRP) test, a powerful tool which may help assess cardiovascular risk. It is a biomarker of inflammation, and hs-CRP’s ability to predict heart disease is both fascinating and complex. We’ll explore how chronic inflammation affects the heart, what high hs-CRP…
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In this episode we explore the surprising link between sleep deprivation and weight gain. Discover how hormones like leptin and ghrelin, which regulate hunger and metabolism, are thrown off balance when we don't get enough sleep. We'll break down the science behind why losing sleep can lead to increased hunger, stress eating, and obesity, and how e…
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In this episode we explore the vital role that HDL cholesterol plays in maintaining cardiovascular health. Known as "good cholesterol," HDL helps clear excess fats from the bloodstream, but recent research shows that its role is far more complex than we once thought. We'll discuss how low HDL levels are linked to increased heart disease risk, why s…
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In this episode, we take a microscopic look at how some of the most dangerous RNA viruses, like COVID-19, Ebola, RSV, and the flu, hijack our cells to replicate. Discover the science behind viral reproduction and RNA-dependent RNA polymerase, the specialized machinery these viruses rely on. We’ll also explore how new antiviral treatments based on R…
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This week we dive deep into the mysteries of chronic cough—a condition that affects millions worldwide and can last for months or even years. In this episode, we’ll explore the science behind why we cough, how chronic cough disrupts lives, and the latest research on treatments and potential cures. From overactive nerve responses to underlying healt…
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In this episode, we compare the looming disaster of the Death Star to the health risks of Metabolic Syndrome, a combination of factors that significantly increase the chances of serious conditions like diabetes, heart disease, and stroke. Just as the Death Star’s vulnerability came from multiple issues working together, Metabolic Syndrome results f…
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In this week's episode, we’re using a historical naval mishap as a metaphor to explain how asthma works. Much like the Spanish ships accidentally firing on their own allies in 1801, asthma is caused by your immune system misfiring—targeting harmless particles like dust or allergens and causing inflammation in your airways. We’ll dive into the mecha…
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In this episode, we delve into the fascinating world of kidneys, those incredible organs that tirelessly filter our blood and regulate our body’s fluids. We’ll explore the complexities of autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that affects a small percentage of the population but can lead to severe outcomes like k…
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In this episode, we explore the fascinating history of flu treatments, from bizarre and dangerous remedies of the past to the cutting-edge vaccines of today. We'll dive into the strange and often misguided methods used before the modern era, including addictive drugs, oysters, chloroform, and even chemical warfare agents. As we move into modern tim…
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In this episode, we delve into the gritty details of the stomach flu, focusing on the notorious Norovirus (stomach bug). Once overshadowed by Rotavirus, Norovirus now leads the charge in causing widespread acute gastroenteritis across all ages. We'll explore its symptoms, transmission, and why it thrives in closed environments like schools and crui…
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In this episode, we dive deep into the world of lipids and their crucial role in our bodies. Lipids, or fats, are essential for many bodily functions but pose a challenge when circulating in our watery bloodstream. We explore how the body packages these lipids with apolipoproteins to form lipoproteins, making them safe for transport. We discuss the…
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Curious about cannabis and migraines? In this episode, we explore the intriguing connection between the two. Discover how cannabis, historically used for headache relief, is making a comeback in medical circles despite legal hurdles. We dive into the endocannabinoid system, THC, CBD, and their potential impacts on migraine pathways. Learn about the…
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Join us as we dive into the complexities of memory and its fascinating mechanisms. We'll explore the different types of memory, how they're formed, stored, and retrieved, and the various brain regions involved. Discover the stark differences between implicit and explicit memory, and learn why conditions like Alzheimer's and other forms of dementia …
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In this episode, we dive into the world of blepharitis, a common yet often misunderstood condition that causes inflammation of the eyelids. Affecting people of all ages and backgrounds, blepharitis leads to symptoms such as eye irritation, redness, swelling, and dryness, significantly impacting quality of life. We'll explore the various causes, inc…
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In this episode, we dive deep into the complexities of diabetes beyond just managing blood sugar levels. Learn how uncontrolled diabetes impacts several parts of the body, causing serious complications due to blood vessel damage. We'll explore microvascular complications like diabetic retinopathy and nephropathy, as well as macrovascular issues suc…
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In this episode, we explore the complexities of rheumatoid arthritis (RA), a chronic autoimmune inflammatory disease affecting millions worldwide. RA causes the immune system to attack healthy joint tissue, leading to pain, stiffness, swelling, and serious complications such as joint and bone damage, and organ issues. We'll discuss the factors cont…
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In this episode, we explore the intricate world of migraines, a condition affecting one in eight people globally. Discover the five phases of a migraine—prodrome, aura, headache, postdrome, and interictal—and how each contributes to the overall experience. We delve into the role of the hypothalamus, the brain's stability center, in triggering migra…
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In today's episode, we delve into Chronic Obstructive Pulmonary Disease (COPD), a debilitating lung condition affecting millions worldwide. Characterized by obstructed airflow, COPD's symptoms—ranging from persistent cough and phlegm to life-threatening exacerbations—stem from the progressive degradation of lung structure. This disease is exacerbat…
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In today's episode, we dive into the surprisingly nuanced world of mosquitoes, revealing their role as the deadliest animal on Earth due to their capacity as disease vectors. While shark attacks capture headlines, mosquitoes quietly claim up to a million lives annually by transmitting diseases like malaria, dengue, and yellow fever. We explore the …
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This week's podcast dives into the harrowing legacy of the Tuskegee syphilis study, a dark chapter in American history that began in 1932. This study blatantly ignored ethical principles that and represented a grievous lapse in justice, respect, and beneficence in clinical research. The exposure of this unethical experiment in the 1970s led to sign…
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This podcast explores the evolution of ethical standards in clinical research, highlighted by the Declaration of Helsinki. Initially drafted in response to historical abuses, the Declaration enforces principles ensuring patient well-being, informed consent, and fair treatment across studies. It mandates transparency in protocol, independent reviews…
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Today we delve into the intricate relationship between diabetes and gastrointestinal health, focusing on a condition known as gastroparesis. Gastroparesis slows down the stomach's ability to empty food, a condition exacerbated by diabetes. The episode explores how diabetes disrupts the normal functioning of the enteric nervous system—our body's "se…
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Explore the world of breathing and its complications in this podcast, where we delve into the surprisingly complex mechanism of breathing and the common but often unrecognized condition of obstructive sleep apnea (OSA). Affecting approximately one billion people globally, OSA disrupts sleep by blocking the airway, leading to snoring, restless night…
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In this podcast episode, we explore the crucial role of the gut microbiome, a complex ecosystem within us composed primarily of bacteria that perform essential functions for our health. We discuss how the microbiome influences everything from nutrient absorption to immune response and how its imbalance leads to conditions like ulcerative colitis. H…
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This podcast delves into the prevalent issue of high blood pressure, a condition impacting nearly half of all Americans and contributing to severe health complications like heart attacks and strokes. Despite numerous available medications, many patients struggle with treatment effectiveness and adherence. The episode explores an innovative approach…
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In this enlightening episode, we delve into the pivotal role of sunlight and its influence on our health, focusing on Vitamin D production. Despite widespread belief in the benefits of Vitamin D supplements, research reveals a complex reality. While supplementation does increase Vitamin D levels in the blood, it often fails to alleviate associated …
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In this podcast, we unravel the intricacies of thyroid function and delve into the complexities of hypothyroidism, a condition marked by insufficient thyroid hormone production. The thyroid gland, nestled in the neck and resembling a butterfly, plays a pivotal role in regulating metabolic processes through the synthesis and release of hormones such…
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This April 1st we’re taking a satirical look at manual heart repair using a woven-material-backed pressure sensitive tape. Participate in clinical research! www.ENCOREdocs.com Share with a friend. Rate, Review, and Subscribe to the ENCORE Research Group podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Insta…
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In this Women’s History Month special, we delve into the extraordinary life and groundbreaking work of Dr. Gerty Cori, the first American woman to win a Nobel Prize in Physiology or Medicine. Born into a Jewish family in Prague in 1896, Gerty overcame societal barriers to become a pioneering researcher alongside her husband, Carl Cori. Their collab…
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