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With an expert panel of Doctors from around the World we take our listeners on a journey of discovery, charting the highs and lows of Covid-19's advancement from epidemic to pandemic, retrospective to forward-facing. Guided by our host Dr Efstathios Vassiliadis, we discover the challenges for those practicing on the front line, what have been the impacts to surgery and what are the long term impacts of those challenges on patient care ? Facilitated and Hosted by STERIS and Evnia
 
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show series
 
Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells. Hosts: Vincent Racaniello, Stephanie Langel, Cynthi…
 
The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Antivira…
 
Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this…
 
On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a …
 
On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Intestinal IgA regulates neuroi…
 
On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of …
 
In Episode 2 our panel discuss the current and forward view of the pandemic, what are the challenges that clinical teams face in continuing to care for patients, whilst minimising the wider impact of the virus for non-Covid-19 related health concerns. In the face of immense hospitals pressures compounded by Covid-19 ,How do doctors manage two of th…
 
By taking a global view of the Covid-19 pandemic, we take our listeners on a journey of discovery, charting the highs and lows of the virus's advancement from epidemic to pandemic, retrospective to forward-facing. Guided by our host Dr. Efstathios Vassiliadis, CEO of Evnia we discover the challenges for those practicing on the front line, what have…
 
Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Christian Gaebler Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episo…
 
Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Madina Wane Subscribe (free): iTunes, Google P…
 
Immune reminisces about a year in COVID-19 immunology, Steph’s receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Googl…
 
Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcas…
 
Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker G…
 
Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guests: Alexis Mobley, Jo…
 
Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Alexander Dent Subscribe (f…
 
Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Imm…
 
Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Li…
 
Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CD8 cells defend a…
 
Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email B…
 
Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron…
 
Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immu…
 
Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode ACE2…
 
Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Irene Salinas Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode…
 
Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode H3K4me1 mark on memory-like NK cells (Cell Rep) Lett…
 
Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Michael Mina Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Me…
 
The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CD8+ T cell memory nee…
 
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