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For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™. You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance ...
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You think, you feel, you are—but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical? In this episode, Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Asprey to challenge everything you think you know about the mind, reality, and human potent…
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You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize? In this episode, Scott Barry Kaufman, Ph.D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets. He …
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What do vibrations and the psychedelic experience have in common? MDMA therapy is revolutionizing mental health treatment, helping people overcome PTSD, anxiety, and emotional trauma with unprecedented success. But what if you could tap into those same powerful benefits—without taking a single drug? It turns out your brain responds to more than jus…
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Your Brain is Lying to You—Here’s How to Take Back Control Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you? In this episode, Bizzie Gold, mind architect and creator of The Break Method, joins Dave Asprey to expose the se…
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Is the Way You Speak Limiting How You Think? For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations. In this mind-bending episode, linguist Daniel Everett…
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For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story? Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of genetic optimization—how understanding your DNA can unl…
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For years, we’ve been told that willpower and repetition are the keys to forming habits. But the truth is, habits don’t stick because of repetition—they stick because of emotion! In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change…
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In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below …
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Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, en…
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Could a single molecule be the difference between vibrant longevity and early decline? Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD. This master molecule fuel…
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Welcome to the metabolism masterclass! Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just y…
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Most people wait for inspiration. But what if you could train your brain to create on demand? Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius? In this must-listen episode, Rick sits down wi…
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What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle? Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic p…
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From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back? In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke fre…
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Could the right form of a single vitamin be the difference between thriving and barely surviving? In this Part 2 conversation, human biologist and longevity expert Gary Brecka reveals the #1 overlooked factor that’s wrecking your health: methylation—your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, an…
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Why were our grandparents stronger, healthier, and living longer—without the “advancements” of modern medicine? Gary Brecka, one of the world’s leading experts in human longevity and performance, exposes the hidden crisis that’s wrecking your hormones, slashing your energy, and cutting your lifespan short. In this no-holds-barred conversation with …
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Billy Carson, a Harvard-certified expert in ancient civilizations and an MIT-trained scholar in neuroscience, has spent decades decoding the mysteries of lost technology, quantum reality, and human optimization. Alongside Elisabeth Carson, a biohacker and neuroscience researcher, they bridge the gap between ancient wisdom and modern science—reveali…
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Everything you’ve been told about weight loss is a lie! In this episode, Dr. Nick Norwitz, a metabolic health expert with accolades from Oxford and Harvard, joins Dave to expose the biggest myth in dieting: Calorie Counting. Together, they dismantle outdated weight-loss advice and reveal the truth about metabolism that could revolutionize your heal…
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What if the key to living longer isn’t avoiding stress—but mastering it Jeff Krasno, founder of Commune and renowned stress expert, joins Dave to reveal why most of us have stress all wrong. In this fascinating conversation, Jeff redefines how we think about stress—showing how it can be your greatest ally instead of your worst enemy. From his groun…
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What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive? Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach emb…
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Is there actual “magic” on this planet, or is it just in the movies? Dr. Barry Morguelan, a top surgeon and one of only nine living grandmasters of an ancient Lao Tzu lineage, joins Dave to share secrets that have been hidden for 5,000 years. Together, they explore how the principles behind quantum physics, energy mastery, and timeless healing tech…
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What happens when nearly 60 years of combined biohacking expertise collide in one podcast? Peter Diamandis is a world-renowned futurist, space entrepreneur, and innovator behind groundbreaking ventures like the XPRIZE and Abundance 360. Dave sits down with Peter to combine their nearly 60 years of biohacking expertise, delivering the ultimate playb…
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What if you could ditch your glasses forever by simply doing a 10-minute exercise each day? In this episode, Dave sits down with Dr. Bryce Appelbaum, a visionary in vision biohacking, to uncover how simple techniques can transform your eyesight. From near-far focusing to eye stretches, these exercises don’t just improve your vision—they enhance you…
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What if the secret to living to 250 was simply sitting in the garden? In this episode, Dave sits down with Christian Drapeau, a leading expert in stem cell science, to explore the plants and natural practices that could unlock extreme longevity. From goji berries to reishi mushrooms, these age-old remedies do more than nourish—they activate your bo…
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Are we protecting our kids—or unknowingly putting their health at risk? Dr. Joel “Gator” Warsh isn’t just another pediatrician; he’s a bold voice speaking out on the vaccine debate that’s dividing parents, doctors, and society. In this episode, we pull back the curtain on one of the most censored and controversial topics of our time. With his integ…
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